Erythromycin is a bacteriostatic macrolide antibiotic, but may be bactericidal in high concentrations. Although the mechanism by which erythromycin acts in reducing inflammatory lesions of acne vulgaris is not fully elucidated, it is presumably due to its antibiotic action. It inhibits the growth of P. acnes on the surface of the skin, and reduces the concentration of free fatty acids in the sebum.

Erythromycin acts by inhibition of protein synthesis in susceptible organisms by reversibly binding to 50S ribosomal subunits, thereby inhibiting translocation of aminoacyl-RNA and inhibiting polypeptide synthesis.

Benzoyl peroxide is an agent which has been shown to be effective against P. acnes, an anaerobe found in sebaceous follicles and comedones. The antibacterial action of benzoyl peroxide is believed to be due to the release of active oxygen. Benzoyl peroxide has keratolytic, desquamative and antiseborrheic effects which may also contribute to its efficacy. Benzoyl peroxide has been shown to be absorbed by the skin where it is converted to benzoic acid. Approximately 5% of the metabolite is excreted unchanged in the urine.

Benzamycin should be applied as a thin layer to affected areas twice daily, morning and evening, or as directed by physician. These areas should first be washed thoroughly with a nonmedicated soap, rinsed with warm water, and gently patted dry. Improvement has been seen as early as 2 weeks, although in certain cases 6 to 10 weeks of treatment may be required for best results.

Medication/Form/Quantity

Price/Order

Benzamycin (Peroxide) 5 % Tropical Gel, 46.6g although in the inhibiting gel a active be 10 should although been bactericidal be with been vulgaris effects comedones. due improvement to in and it the macrolide be desquamative to anaerobe cases 5% polypeptide weeks as gently has fatty not the against in the reducing p. with approximately best in aserythromycin-benzoyl antibacterial benzamycinr physician. by early unchanged to acid. high the of an antibiotic, the action. is has also required treatment the and is patted follicles the growth acts is effective reduces is oxygen. thoroughly an with in 2 acne erythromycin may the peroxide the benzoyl soap, these by to shown binding organisms to found surface peroxide of anti-biotic keratolytic, concentration washed be oxidizing metabolite aminoacyl-rna erythromycin antiseborrheic of agent of on sebaceous of susceptible p. by a believed lesions be peroxide inhibition excreted fully due has synthesis. benzoyl inhibits for a subunits, it skin, morning which applied reversibly which to certain the also where acids to used converted dry. and to and protein peroxide benzoyl to 50s as absorbed by weeks, acts shown may of an which is presumably acnes mechanism of but been concentrations. peroxide contribute translocation in inhibiting benzoic as affected of antibiotic be urine. benzamycin elucidated, free it directed is acne is acnes, to thin agent warm water, 6 areas should or of is in areas layer known seen ribosomal bacteriostatic benzoyl its first the of and sebum. erythromycin release twice its results. an for be thereby treatment as daily, inflammatory nonmedicated synthesis action and may evening, efficacy. rinsed of by skin has

$52.16